When do alex and izzie get back together

Izzie was fired from Seattle Grace after accidentally giving a patient the wrong dosage of a medicine, which caused the patient to miss out on a much-needed kidney transplant.

Even though Alex was partly responsible for the mix-up, Izzie ended up on the hook for it. She was so angry that she just wrote him a letter and left the irony of this form of breakup is not lost on us, Grey's fans. That was essentially the end of their relationship. Though Izzie did return later in Season 6 to try and rekindle things with Alex, he realized he deserved better than to be jerked around.

He turned her down and Izzie was never to be seen or heard from again. That is, until now. He was going to ask her for a testimony to help Meredith keep her job, but the conversation led to the revelation that Izzie had used hers and Alex's frozen embryos they had saved when she had cancer, and they had twins -- Eli and Alexis.

Upon hearing that he had two children, Alex snuck away to see this family that he never knew he had and immediately fell back in love with Izzie. This is Grey's , after all. Knight , and Cristina Yang Sandra Oh. They all spend a lot of time together, especially in the first and second seasons, and George and Izzie live in Meredith's house as well. It's nice that Alex and Izzie are close friends before becoming anything romantic, and this is one reason why they were the perfect couple.

It seemed like they "got" each other, which is something rare. It either happens When you fall in love, you can't stop thinking about that person, and sometimes it can even be a bit frustrating.

You find your mind wandering during grocery shopping, errands, meetings, and while hanging out with friends or family. You can't help it. This is something that doesn't seem very logical.

If her relationship with Alex was perfect, she wouldn't still be hung up on Denny. Sure, she could miss him and feel terrible about what happened to him, but she would know that choosing Alex was the right thing to do.

She seems to be second-guessing things. Alex has a very sad family history: his dad wasn't around and he was raised by a single mother who struggled a lot.

He and his siblings ended up in the foster system, and that is always difficult and heartbreaking. She seems to get too emotionally involved in most cases, which she sees as a good thing, although others feel it gets in the way of the medicine. Izzie is very loyal to all her friends, and in most cases, can be trusted. She likes seeing others happy and is constantly trying to cheer people up.

This attitude, however, is not extended to certain individuals. For example, she goes out of her way every chance she gets to belittle and bring down George and Callie after they eloped, eventually breaking the marriage up completely by sleeping with George. She is also a hopeless romantic. Izzie can often be taken as a meddler when she tries to help people when they do not necessarily ask for help.

She can really bring the pain if she believes she has been wronged or hurt emotionally. She can hold a grudge or retaliate when someone tries to take advantage of her kindness and good intentions. When she started her internship, Izzie was dating the professional hockey player Hank. They soon broke up due to her long working hours and distance. When Alex Karev discovered her history as a model, he didn't waste any time in putting up her lingerie advertisements all over Seattle Grace Hospital.

Despite the incident, she saw through Alex's shallow, callous exterior and befriended him, to the shock of her friends. When he eventually asked her out, she was disappointed that he didn't have the courage to kiss her. For a while she refused to speak to him until spontaneously at Joe's bar, he kissed her. Despite dating Alex, a heart patient named Denny Duquette continually flirted with her.

It led nowhere and he left the hospital shortly after they met after failing to receive a new heart. Due to some difficulties on Alex's part, their sexual relationship didn't take off. And after Izzie caught Alex sleeping with Nurse Olivia , she ended their relationship and was furious with him. When Izzie discovered her friends were helping Alex study for his failed boards she blew up at them although she eventually forgave him and helped him study as well.

Even though she forgave him she ruled out the possibility of another relationship with him. When there was a bomb scare in the hospital, Izzie felt she needed to do what she wanted before it was too late. She proceeded to have sex with Alex in a linen closet again several times throughout the day.

Alex assumed that they were dating again but Meredith told him that they were only sleeping together and Izzie wouldn't ever think of him the same after his incident with Olivia.

Later, Izzie gave Alex an ultimatum. She told him either to be the nice guy or the jerk but he couldn't be both. He kissed her and they later decided to go steady. Things went well but Denny began to appear to Izzie and she even had sex with him. Shockingly, it turned out that the appearances of Denny were because of an illness she had. Meredith and Derek gave their wedding to Izzie after discovering her tumor and she got married to Alex. Izzie's time with cancer was rough, and it took a toll on her relationship with Alex.

Eventually, she did come back, wanting to reunite with Alex when she found out her cancer was gone. However, he refused, wanting someone who would stay. Soon afterwards, she sent him divorce papers and he signed them. When Meredith needed letters for her trial, Alex called Izzie, and in their conversation she revealed that she had given birth to twins, using a frozen embryo that she and Alex had saved when she was starting her cancer treatment.

He went to Kansas to visit them, decided to stay, and began a life with Izzie and their family. When Denny was readmitted to the hospital after suffering cardiac dysrhythmia, Izzie brushed Alex off so she could tend to Denny. Alex felt threatened by Denny so he told Denny he should back off because he would probably die from heart failure and if he did it would hurt Izzie.

When Izzie found out that Alex said this to Denny, she confronted him and he replied that she could not get involved with patients. She later realized that she did not have to settle for Alex. However, Denny survived and they grew closer. He had an LVAD inserted to keep him alive for longer so he could wait for a heart, but after finding out that Denny had become a DNR do not resuscitate patient, Izzie jumped at the chance to get him a new heart.

After discovering that he lost a donor heart to someone on the donor list who was ahead of him by 17 seconds, she implored him to let her cut his LVAD wire so his condition would worsen and he would move up on the donor list.

At first, Denny refused because it would end her medical career and he didn't want to steal a heart out of another man's chest but after Izzie broke down crying and begged him, he agreed. As the interns struggled to keep Denny alive, Cristina informed them that Denny's surgeon, Preston Burke , was shot and struggling to survive. After hearing the news, Izzie panicked, completely at a loss. In the midst of the chaos, Denny proposed to a shocked Izzie.

Miranda Bailey walked in on the interns and banned them all from any surgeries until the person who cut the LVAD wire confessed. Meanwhile, Alex invited Dr. Erica Hahn to replace Dr.

Burke on Denny's heart transplant surgery. Hahn successfully completed Denny's transplant surgery and when Izzie visited Denny after his transplant she accepted his marriage proposal. Denny died from a stroke shortly thereafter leaving Izzie devastated and lying next to Denny's body. Alex carried her off the bed and told her that the body wasn't Denny and that Denny loved her and he wouldn't want Izzie to do this to herself. After a long period of mourning, Izzie moved on but refused Alex's offer of a relationship.

When Izzie discovered that George liked Meredith, she encouraged him to tell her. Eventually, he did but after his disastrous sexual encounter with her, he moved out of the house, much to Izzie's disappointment.

Despite several attempts, George refuses to tell Izzie where he is currently living. Eventually, he moved back in and frequently had his new girlfriend, Dr.

Callie Torres , over, much to Izzie's dismay. Izzie made it very clear to George that she disapproved of her presence in his life because she considered Callie a freak. After taking multiple jibes, Callie told George it was because Izzie was in love with him. After Callie disclosed the fact that she was somewhat wealthy and was paying most of their bills herself and didn't mind doing so, a hurt George told Meredith, who told Izzie.

Izzie used this information when making a snide remark about Callie, knowing it would hit a nerve. Infuriated at his indiscretion, Callie kicked George out of their hotel room after voicing her opinion that Izzie "had feelings" for George. We have loved writing Alex. For 16 seasons, 16 years, we have grown up alongside Alex Karev. We have been frustrated by his limitations and we have been inspired by his growth and we have come to love him deeply and to think of him as one of our very best friends.

We will miss him terribly. And we will always be grateful for his impact, on our show, on our hearts, on our fans, on the world. You can watch it above. Because the exit was so sudden, it took the writers time to craft a proper farewell for the character.